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Table 3 Association with disease severity measures in early rheumatoid arthritis and in autoantibody-positive/antibody-negative disease

From: Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort

RA cohort

Erosions

Swollen joint count

Health Assessment Questionnaire

 

Erosive, n(%)

Per-allele OR (95% CI)

P trend adj.a

Mean (95% CI)

Coefficient (95% CI)

P trend adj.a

Mean (95% CI)

Coefficient (95% CI)

P trend adj.a

HLA-DRB1 shared epitope

554 (21.5)

  

n = 587

  

n = 587

  

   Negative

175 (22.9)

0.88

0.398

10.5 (9.5 to 11.5)

-0.03

0.455

1.35 (1.24 to 1.47)

-0.00

0.965

   One copy

278 (20.9)

(0.65 to 1.19)

 

9.4 (8.7 to 10.1)

(-1.04 to 0.47)

 

1.38 (1.29 to 1.46)

(-0.09 to 0.09)

 

   Two copies

101 (20.8)

  

9.7 (8.4 to 11.0)

  

1.27 (1.14 to 1.41)

  

PTPN22 (rs2476601)

580 (20.7)

  

n = 468

  

n = 468

  

   GG

423 (22.0)

0.75

0.189

9.5 (8.8 to 10.2)

-0.02

0.593

1.32 (1.23 to 1.40)

0.06

0.133

   GA

147 (17.0)

(0.48 to 1.16)

 

9.0 (7.8 to 10.1)

(-1.31 to 0.75)

 

1.43 (1.30 to 1.56)

(-0.03 to 0.21)

 

   AA

10 (20.0)

  

10.4 (1.9 to 18.9)

  

1.48 (0.35 to 2.61)

  

OLIG3/TNFAIP3 (rs6920220)

551 (20.3)

  

n = 468

  

n = 468

  

   GG

302 (19.9)

1.03

0.853

9.4 (8.6 to 10.1)

0.04

0.291

1.36 (1.27 to 1.45)

-0.01

0.880

   GA

217 (20.7)

(0.73 to 1.46)

 

9.3 (8.3 to 10.2)

(-0.39 to 1.31)

 

1.36 (1.24 to 1.48)

(-0.11 to 0.09)

 

   AA

32 (21.9)

  

10.5 (7.7 to 13.3)

  

1.07 (0.76 to 1.37)

  

STAT4 (rs7574865)

476 (20.4)

  

n = 468

  

n = 468

  

   GG

271 (22.1)

0.82

0.291

9.5 (8.7 to 10.2)

0.01

0.873

1.38 (1.28 to 1.47)

-0.06

0.193

   GT/

170 (18.2)

(0.57 to 1.19)

 

9.3 (8.2 to 10.3)

(-0.82 to 0.97)

 

1.35 (1.23 to 1.46)

(-0.17 to 0.04)

 

   TT

35 (17.1)

  

9.5 (7.0 to 12.0)

  

1.12 (0.85 to 1.39)

  

TRAF1/C5 (rs10760130)

474 (20.3)

  

n = 468

  

n = 468

  

   AA

140 (16.4)

1.18 (0.86 to 1.61)

0.311

9.7 (8.6 to 10.8)

-0.03

0.502

1.25 (1.11 to 1.38)

0.09

0.031

   GA

225 (22.7)

  

9.1 (8.3 to 9.9)

(-1.07 to 0.52)

 

1.34 (1.24 to 1.43)

(0.01 to 0.19)

 

   GG

109 (20.2)

  

9.6 (8.4 to 10.8)

  

1.50 (1.35 to 1.65)

  
  1. CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis. aAdjusted for symptom duration (all cases having a symptom duration <24 months).
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Arthritis Research & Therapy

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