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Table 3 Association with disease severity measures in early rheumatoid arthritis and in autoantibody-positive/antibody-negative disease

From: Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort

RA cohort Erosions Swollen joint count Health Assessment Questionnaire
  Erosive, n(%) Per-allele OR (95% CI) P trend adj.a Mean (95% CI) Coefficient (95% CI) P trend adj.a Mean (95% CI) Coefficient (95% CI) P trend adj.a
HLA-DRB1 shared epitope 554 (21.5)    n = 587    n = 587   
   Negative 175 (22.9) 0.88 0.398 10.5 (9.5 to 11.5) -0.03 0.455 1.35 (1.24 to 1.47) -0.00 0.965
   One copy 278 (20.9) (0.65 to 1.19)   9.4 (8.7 to 10.1) (-1.04 to 0.47)   1.38 (1.29 to 1.46) (-0.09 to 0.09)  
   Two copies 101 (20.8)    9.7 (8.4 to 11.0)    1.27 (1.14 to 1.41)   
PTPN22 (rs2476601) 580 (20.7)    n = 468    n = 468   
   GG 423 (22.0) 0.75 0.189 9.5 (8.8 to 10.2) -0.02 0.593 1.32 (1.23 to 1.40) 0.06 0.133
   GA 147 (17.0) (0.48 to 1.16)   9.0 (7.8 to 10.1) (-1.31 to 0.75)   1.43 (1.30 to 1.56) (-0.03 to 0.21)  
   AA 10 (20.0)    10.4 (1.9 to 18.9)    1.48 (0.35 to 2.61)   
OLIG3/TNFAIP3 (rs6920220) 551 (20.3)    n = 468    n = 468   
   GG 302 (19.9) 1.03 0.853 9.4 (8.6 to 10.1) 0.04 0.291 1.36 (1.27 to 1.45) -0.01 0.880
   GA 217 (20.7) (0.73 to 1.46)   9.3 (8.3 to 10.2) (-0.39 to 1.31)   1.36 (1.24 to 1.48) (-0.11 to 0.09)  
   AA 32 (21.9)    10.5 (7.7 to 13.3)    1.07 (0.76 to 1.37)   
STAT4 (rs7574865) 476 (20.4)    n = 468    n = 468   
   GG 271 (22.1) 0.82 0.291 9.5 (8.7 to 10.2) 0.01 0.873 1.38 (1.28 to 1.47) -0.06 0.193
   GT/ 170 (18.2) (0.57 to 1.19)   9.3 (8.2 to 10.3) (-0.82 to 0.97)   1.35 (1.23 to 1.46) (-0.17 to 0.04)  
   TT 35 (17.1)    9.5 (7.0 to 12.0)    1.12 (0.85 to 1.39)   
TRAF1/C5 (rs10760130) 474 (20.3)    n = 468    n = 468   
   AA 140 (16.4) 1.18 (0.86 to 1.61) 0.311 9.7 (8.6 to 10.8) -0.03 0.502 1.25 (1.11 to 1.38) 0.09 0.031
   GA 225 (22.7)    9.1 (8.3 to 9.9) (-1.07 to 0.52)   1.34 (1.24 to 1.43) (0.01 to 0.19)  
   GG 109 (20.2)    9.6 (8.4 to 10.8)    1.50 (1.35 to 1.65)   
  1. CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis. aAdjusted for symptom duration (all cases having a symptom duration <24 months).