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Table 2 The rearranged heavy chain variable segment genes, their functionality, respective germline gene (homology), ratio of mutations leading to amino acid replacement to silent mutations with the number of mutations for the complementarity determining region and the framework region, heavy chain joining segments and CDR3 lengths

From: B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection

VH Gene Functionality Germline Homology (%) R:S ratio CDR R:S ratio FR JH CDR3 (base pairs)
1 F5-3b6 nf DP6 97 0 2/0 6 26
  F5-3a3 pf DP7 91 4/0 4/4 3 24
  F5-2c2 pf DP14 100 0 0 2 30
  F5-2c6 pf DP14 99 0 0 6 30
  2c-3m4b pf DP25 89 5/6 3/10 3 39
  F5-5c6 pf DP25 92 9/1 4/2 6 39
  F5-2c4* pf DP21 99 0 2/1 1 or 2 or 4 21
  3a-5m3 pf DP21 100 0 1/0 5 18
  F5-3a6 pf DP10 98 2/0 1/0 6 36
  5c-4m4 pf DP10 88 9/2 11/7 4 or 5 18
  F5-3a2 pf DP75 97 2/1 3/1 1 27
  F5-5c1 pf DP75 98 0/0 2/0 1 30
  F5-5c2 nf DP75 96 1/2 2/0 Undetermined 23
  5c-4m7 pf DP75 93 6/2 4/4 4 30
2 2c-VH24s pf HUMIGVH2e 97 1/1 2/0 4 45
  5c-VH22s pf HUMIGVH2e 99 1/1 0/0 2 36
  5c-VH26s pf HUMIGVH2f 95 2/1 2/5 6 15
3 2c-17m14 pf DP54 95.5 3/2 4/2 2 or 5 30
  2c-19m8 pf DP54 95.5 4/1 3/2 4 12
  3a-19m6 pf DP54 95.5 3/0 5/2 4 12
  3b-18m4 nf DP54 100 0/0 0/1 3 23
  5c-21m1 nf DP54 96.7 5/0 1/0 5 or 6 22
  2c-18m7 pf DP47/V3-23 92.4 8/2 2/4 3 30
  2c-21m2 pf DP47/V3-23 96.9 3/0 2/2 6 33
  2c-21m3 pf DP47/V3-23 90.1 7/6 3/3 6 45
  3a-19m8 pf DP47/V3-23 93.3 3/2 6/4 4 24
  F5-3a21 pf DP47/V3-23 92.9 2/0 4/2 5 or 6 45
  5c-19m9 pf DP47/V3-23 95.5 3/3 4/0 4 33
  5c-21m5 pf DP47/V3-23 88.4 10/1 8/6 6 27
  F5-5c18 pf DP47/V3-23 91.2 6/1 3/3 3 24
  3b-17m1 pf DP46 96.9 2/1 2/1 2 42
  F5-3b21 pf DP46 95.9 0/1 1/1 6 21
  2c-20m10 nf DP50 85.7 5/2 10/0 5 26
  3a-16m4 pf DP50 95.8 4/1 0/3 1 36
  3b-17m6 pf DP50 93.3 7/2 4/2 2 or 4 36
  5c-19m7 nf DP50 87.8 7/2 5/1 4 31
  5c-20m8 pf DP50 91.1 9/3 5/3 5 24
  2c-17m9 pf DP49 88.8 3/4 8/10 2 6
  2c-20m9 pf DP49 93.8 5/1 6/2 5 24
  5c-19m4 nf DP49 94.0 5/3 5/0 4 30
  2c-20m8 pf DP51 98.2 0/0 3/1 5 27
  3b-16m4 pf DP51 93.3 6/2 4/3 1 27
  5c-20m6 nf DP51 90.2 13/2 1/6 5 29
  2c-19m2 pf DP31 97.8 2/2 1/0 4 18
  F5-3a17 pf DP31 88 5/2 2/1 2 36
  3a-18m2 pf DP31 93.6 4/0 2/1 3 12
  3a-19m2 pf DP31 97.3 2/1 0/1 4 30
  2c-18m3 pf DP35 100 0/0 0/0 3 24
  2c-19m7 pf DP35 94.6 4/2 4/2 4 33
  5c-21m8 nf DP35 94.6 3/1 0/5 6 31
  3a-20m7 pf DP77 88.3 12/2 9/4 5 33
  F5-5c16 pf DP77 94.3 4/0 6/2 1 27
  2c-21m6 nf DP52 98.2 0/0 2/0 6 25
  3a-18m5 pf DP29 89.9 6/1 9/2 3 39
  5c-21m2 pf DP53 97.3 3/0 2/1 6 12
4 3a-VH43b pf HUMIGHCAK 97 1/2 4/1 3 27
  5c-VH44a pf HUMIGHCAK 95 8/1 3/1 6 24
  3b-VH45a pf DP63 93 4/0 7/4 4 23
  5c-VH44c pf DP63 99 0/1 0/0 4 27
  5c-VH41a nf DP71 99 0/0 3/0 1 12
  5c-VH42c pf HUMIGHCAG 98 1/0 3/0 2 30
  5c-VH46b pf HUMIGHCAG > 99 1/0 0/0 6 45
5 2c-VH53b pf DP73 97 3/0 4/0 3 45
  2c-VH53c pf DP73 95 2/1 8/0 3 48
  2c-VH54c pf DP73 85 12/1 16/6 4 33
  2c-VH54b pf DP73 95 4/1 4/3 4 or 6 39
  3a-Vh53s pf DP73 96 5/0 3/4 3 66
  3a-VH54s pf DP73 100 0/0 0/0 4 36
  3a-VH56s nf DP73 90 13/1 7/0 5 or 6 31
  3b-VH53s pf DP73 95 4/1 5/2 3 or 5 12
  1. pf, Potentially functional; nf, nonfunctional. Referred germline genes: 'DP' [34]; 'HUMIGHCAG' and 'HUMIGHCAK' [35]; 'HUMIGVH2E' [36]. EMBL accession numbers: AJ298233-44, AJ303356-58, AJ306240-68, AJ407969-98. * Identical to F5-3a4, F5-3b4, 5c-4m6.
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Arthritis Research & Therapy

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