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Table 4 Association of HLA-DRB1 alleles with the SE, HLA-DR3, and DERAA motif with ACPA+ or ACPA- rheumatoid arthritis

From: Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor

   Controls
(n = 269)
Rheumatoid arthritis patients
(n = 231)
    ACPA+(n = 143) ACPA-(n = 88)
     P value OR, 95% CI   P value OR, 95% CI
SE Absence, n (%) 157 (58.4) 46 (32.2) 0.0001 2.95, 1.93-4.53 57 (64.8) 0.31 0.76, 0.46-1.27
  Presence, n (%) 112 (41.6) 97 (67.8)    31 (35.2)   
DR3 Absence, n (%) 216 (80.3) 125 (87.4) 0.07 0.58, 0.32-1.04 63 (71.6) 0.10 1.61, 0.93-2.80
  Presence, n (%) 53 (19.7) 18 (12.6)    25 (28.4)   
DERAA Absence, n (%) 197 (73.2) 118 (82.5) 0.03 0.58, 0.34-0.64 58 (65.9) 0.22 1.41, 0.84-2.37
  Presence, n (%) 72 (26.8) 25 (17.5)    30 (34.1)   
  1. ACPA, anti-citrullinated protein antibody; CI, confidence interval; DERAA, DERAA-encoding allele; DR3, HLA-DR3; OR, odds ratio; SE, shared epitope allele.