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Table 5 Association of HLA-DR3 and DERAA-encoding alleles stratified by the presence of shared epitope alleles with ACPA+ rheumatoid arthritis

From: Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor

   Controls
(n = 269)
ACPA-positive RA patients
(n = 143)
     Pvalue OR (95% CI)
SE-positive DR3-positive 16 (14.3) 8 (8.2) 0.17 0.53 (0.22-1.22)
  DR3-negative 96 (85.7) 89 (91.8)   
SE-negative DR3-positive 37 (23.6) 10 (21.7) 0.84 0.90 (0.40-1.98)
  DR3-negative 120 (76.4) 36 (78.3)   
SE-positive DERAA-positive 14 (12.5) 10 (10.3) 0.85 0.58 (0.34-1.90)
  DERAA-negative 98 (87.5) 87 (89.7)   
SE-negative DERAA-positive 58 (36.9) 15 (32.6) 0.72 0.82 (0.41-1.65)
  DERAA-negative 99 (63.1) 31 (67.4)   
  1. Percentages relate to total SE-positive or SE-negative controls.
  2. ACPA, anti-citrullinated protein antibody; CI, confidence interval; DERAA, DERAA-encoding allele; DR3, HLA-DR3; OR, odds ratio; RA, rheumatoid arthritis; SE, shared epitope allele.