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Table 3 Baseline demographics and clinical characteristics of abatacept clinical trial patients and RA DMARD cohorts

From: Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment

 

Abatacept CDP

(N = 4,134)

BC

(N = 12,337)

NDB

(N = 10,499)

PharMetrics

(N = 52,444)

NOAR

(N = 523)

Sweden ERA

(N = 3,703)

Sweden Inpatient

(N = 53,067)

Age, n (%)

       

   18 to 44

1,015 (25)

3,088 (25)

1,442 (14)

15,733 (30)

109 (21)

782 (21)

4,776 (9)

   45 to 74

2,988 (72)

7,840 (64)

7,586 (73)

35,137 (67)

366 (70)

2,421 (66)

29,718 (56)

   ≥ 75

131 (3)

1,409 (11)

1,438 (14)

1573 (3)

48 (9)

500 (14)

18,573 (35)

Female, n (%)

3,323 (80)

8,936 (72)

7,971 (76)

18,569 (76)

357 (68)

2,589 (70)

37,678 (71)

Duration of RA, n (%)

       

   <5 years

1,353 (33)

4,890 (40)

2,726 (29)*

NA

523

3,703

NA

   5 to 10 years

1,192 (29)

4,206 (34)

1,902 (20)*

NA

0

0

NA

   >10 years

1,586 (38)

3,241 (26)

4,716 (50)*

NA

0

0

NA

Concomitant medications, n (%)†

       

   Oral corticosteroids

2,657 (64)

8,121 (66)

4,588 (44)

11,504 (48)

194 (37)

NA

NA

   NSAIDS

3,113 (75)

11,001(89)

6,820 (65)

NA

416 (80)

NA

NA

Total follow-up (years)

       

   Mean

2.1

4.9

3.3

2.2

7.9

3.6

5.6

   Median

1.8

6.0

2.5

2.0

9.3

NA

NA

  1. *RA duration was not collected for every subject in the NDB; therefore, n = 9,344 for this variable. †Use of concomitant medications at baseline is presented for the abatacept trial population, whereas, use during follow-up is presented for the RA cohorts (where available). BC, British Columbia population-based RA Cohort; NDB, National Data Bank for Rheumatic Diseases; NOAR, Norfolk Arthritis Register; Sweden ERA, Sweden Early Rheumatoid Arthritis Register. NA = not available.