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Table 5 Observed overall incidence rates of tuberculosis in the abatacept CDP and RA cohorts

From: Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment

Cohort

Tuberculosis

IR/100 py (95% CI)

Observed IR

 

   DB Abatacept Population

0.06 (0.0 to 5.6)

   DB Placebo Population

0.13 (0.0 to 5.6)

   Cumulative Abatacept Population (DB + OL)**

0.04 (0.01 to 0.10)

Expected IR

 

   BC

0.03 (0.01 to 0.05)

   NDB

0.02 (0.01 to 0.04)

   PharMetrics

0.02 (0.01 to 0.04)

   NOAR

0.013*

   Sweden ERA

0.026 (0.003 to 0.094)

   Sweden INPT

0.05 (0.04 to 0.06)

  1. *95% CI not available. **n = 3.