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Figure 4 | Arthritis Research & Therapy

Figure 4

From: B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, which are modulated by anti-tumor necrosis factor therapy

Figure 4

Altered regulation of FcγRIIb on B cells from rheumatoid arthritis (RA) patients. (a) Representative histograms of FcγRIIb (CD32b) expression on naïve B cells (gray line), memory B cells (black line), and plasmablasts (dotted line) from an RA patient (left) and a healthy control (right). The shaded curve represents the isotype control. Graphics show a comparison of FcγRIIb expression between naïve B cells, memory B cells, and plasmablasts from 18 RA patients (b) and 13 healthy controls (c). Expression was quantified as mean fluorescence intensity (MFI). The differences in the FcγRIIb expression levels between B-cell subpopulations were analyzed with the two-tailed paired Student t test; ***P < 0.001. Horizontal lines represent mean values. PE, phycoerythrin.

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Arthritis Research & Therapy

ISSN: 1478-6362

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