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Figure 5 | Arthritis Research & Therapy

Figure 5

From: B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, which are modulated by anti-tumor necrosis factor therapy

Figure 5

FcγRIIb expression levels on rheumatoid arthritis (RA) patients' memory B cells are inversely associated with anti-modified and citrullinated vimentin (anti-MCV) titers. (a) FcγRIIb expression on memory B cells from RA patients with high titers (at least 50 U/mL) and from those with no or low titers (less than 50 U/mL) of serum anti-MCV antibodies. Expression was quantified as mean fluorescence intensity (MFI). *P < 0.05, two-tailed Mann-Whitney U test. (b) Anti-MCV antibody titers in patients who downregulated the expression of FcγRIIb (the difference between MFI of naïve B cells and MFI of memory B cells was greater than 10 for downregulators) and in those who upregulated or maintained it almost invariable (the difference between MFI of naïve B cells and MFI of memory B cells was not greater than 10 for non-downregulators). *P < 0.05, two-tailed Mann-Whitney U test. (c) FcγRIIb expression on memory B cells from RA patients with normal levels (less than 1,350 mg/dL) and high levels (at least 1,350 mg/dL) of total serum IgG. Expression was quantified as MFI. P > 0.05, two-tailed Mann-Whitney U test. Horizontal lines represent mean values.

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