Skip to main content
Figure 6 | Arthritis Research & Therapy

Figure 6

From: Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma

Figure 6

Myocardial fibrosis in Tβ RIIΔk-fib transgenic mice. (a) Transgenic animals have significantly higher non-crosslinked collagen content when compared with sex-matched littermate controls (n = 10). Data are expressed as mean ± SEM, *P < 0.05. (b) Picrosirius red stains of the left ventricles of WT and TG animals viewed under bright-field and polarized light microscopy. Transgenic animals have a diffuse increase in collagen deposition within the myocardial interstitium. Original magnification, ×20, representative images from transgenic (n = 6) and wild-type (n = 6) littermate sex-matched controls.

Back to article page