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Table 1 Demographic characteristics and genotype distribution of rheumatoid arthritis patients included in the study

From: A1298C polymorphism in the MTHFRgene predisposes to cardiovascular risk in rheumatoid arthritis

Patients (n) 612
Main characteristics  
   Age at disease onset (years) 49.0 ± 15.1
   Follow up (years) 14.3 ± 9.4
   Women (%) 74.5
   Rheumatoid factor positive (%) 68.5
   Anti-CCP antibodies positive (%) 66.9
   Shared epitope positive (%) 63.6
   Extra-articular manifestations (%) 21.2
   Radiographic erosions in hands and/or feet (%) 64.9
MTHFR 677 C>T polymorphism  
   CC 257 (42.9)
   CT 275 (45.9)
   TT 67 (11.2)
MTHFR 1298 A>C polymorphism  
   AA 286 (48.6)
   AC 242 (41.2)
   CC 60 (10.2)
Medication (%)  
   Patients receiving DMARDs 90.1
   Patients on treatment with methotrexate 84.6
   Patients on treatment with TNFα blockers 17.1
Cardiovascular risk factors (%)  
   Hypercholesterolemia and/or hypertriglyceridemia 19.2
   Hypertension 16.1
   Diabetes mellitus 2.8
   Obesity 5.4
   Smoking 9.1
Patients with cardiovascular eventsa 80 (13.1)
   Ischemic heart disease 37 (4.6)
   Heart failure 5 (2.3)
   Cerebrovascular accidents 32 (5.1)
   Peripheral arteriopathy 6 (1.0)
  1. Data presented as mean ± standard deviation or n(%), except where indicated otherwise. CCP, cyclic citrullinated peptide; DMARDs, disease-modifying anti-rheumatic drugs. aThis category was defined considering the first type of cardiovascular event.