Table 1 Demographic characteristics and genotype distribution of rheumatoid arthritis patients included in the study
From: A1298C polymorphism in the MTHFRgene predisposes to cardiovascular risk in rheumatoid arthritis
Patients (n) | 612 |
Main characteristics | |
Age at disease onset (years) | 49.0 ± 15.1 |
Follow up (years) | 14.3 ± 9.4 |
Women (%) | 74.5 |
Rheumatoid factor positive (%) | 68.5 |
Anti-CCP antibodies positive (%) | 66.9 |
Shared epitope positive (%) | 63.6 |
Extra-articular manifestations (%) | 21.2 |
Radiographic erosions in hands and/or feet (%) | 64.9 |
MTHFR 677 C>T polymorphism | |
CC | 257 (42.9) |
CT | 275 (45.9) |
TT | 67 (11.2) |
MTHFR 1298 A>C polymorphism | |
AA | 286 (48.6) |
AC | 242 (41.2) |
CC | 60 (10.2) |
Medication (%) | |
Patients receiving DMARDs | 90.1 |
Patients on treatment with methotrexate | 84.6 |
Patients on treatment with TNFα blockers | 17.1 |
Cardiovascular risk factors (%) | |
Hypercholesterolemia and/or hypertriglyceridemia | 19.2 |
Hypertension | 16.1 |
Diabetes mellitus | 2.8 |
Obesity | 5.4 |
Smoking | 9.1 |
Patients with cardiovascular eventsa | 80 (13.1) |
Ischemic heart disease | 37 (4.6) |
Heart failure | 5 (2.3) |
Cerebrovascular accidents | 32 (5.1) |
Peripheral arteriopathy | 6 (1.0) |