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Table 2 Frequencies of gene polymorphisms with or without cardiovascular events: 5 years follow up

From: A1298C polymorphism in the MTHFRgene predisposes to cardiovascular risk in rheumatoid arthritis

Polymorphism Cardiovascular event occurrence in RA patients
  Overall 5 years follow up
  + - P value + - P value
MTHFR 1298 A>C (n = 77) (n = 511)   (n = 75) (n = 484)  
   AA 29 (37.7) 257 (50.3) Ref. 29 (38.7) 241 (49.8) Ref.
   AC 36 (46.8) 206 (40.3) 0.10 34 (45.3) 193 (39.9) 0.16
   CC 12 (15.6) 48 (9.4) 0.03 12 (16.0) 50 (10.3) 0.04
   A 94 (61.0) 720 (70.5) Ref. 92 (61.3) 675 (69.7) Ref.
   C 60 (39.0) 302 (29.5) 0.02 58 (38.7) 293 (30.3) 0.04
MTHFR 677 C>T (n = 76) (n = 523)   (n = 75) (n = 492)  
   CC 38 (50.0) 219 (41.9) Ref. 38 (50.7) 210 (42.7) Ref.
   CT 28 (36.8) 247 (47.2) 0.11 27 (36.0) 225 (45.7) 0.12
   TT 10 (13.2) 57 (10.9) 0.98 10 (13.3) 57 (11.6) 0.87
   C 104 (68.4) 685 (65.5) Ref. 103 (68.7) 645 (65.5) Ref.
   T 48 (31.6) 361 (34.5) 0.48 47 (31.3) 339 (34.5) 0.45
  1. Data presented as n (%). Genotypic and allelic frequencies of the 1298 A>C and 677 C>T 5,10-methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in rheumatoid arthritis (RA) patients with (+) or without (-) cardiovascular events in the whole cohort and in patients with 5 years of follow up. Ref., reference.