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Table 3 Frequencies of gene polymorphisms with or without cardiovascular events: 10 years follow up

From: A1298C polymorphism in the MTHFRgene predisposes to cardiovascular risk in rheumatoid arthritis

 

Cardiovascular event occurrence in RA patients

 

Overall

10 years follow up

 

+

-

P value

+

-

P value

MTHFR 1298 A>C

(n = 77)

(n = 511)

 

(n = 64)

(n = 335)

 

   AA

29 (37.7)

257 (50.3)

Ref.

22 (34.4)

160 (47.8)

Ref.

   AC

36 (46.8)

206 (40.3)

0.10

30 (46.9)

142 (42.4)

0.15

   CC

12 (15.6)

48 (9.4)

0.03

12 (18.8)

33 (9.9)

0.01

   A

94 (61.0)

720 (70.5)

Ref.

74 (57.8)

462 (69.0)

Ref.

   C

60 (39.0)

302 (29.5)

0.02

54 (42.2)

208 (31.0)

0.01

MTHFR 677 C>T

(n = 76)

(n = 523)

 

(n = 63)

(n = 347)

 

   CC

38 (50.0)

219 (41.9)

Ref.

31 (49.2)

152 (43.8)

Ref.

   CT

28 (36.8)

247 (47.2)

0.11

24 (38.1)

153 (44.1)

0.37

   TT

10 (13.2)

57 (10.9)

0.98

8 (12.7)

42 (12.1)

0.87

   C

104 (68.4)

685 (65.5)

Ref.

86 (68.3)

457 (65.9)

Ref.

   T

48 (31.6)

361 (34.5)

0.48

40 (31.7)

237 (34.1)

0.64

  1. Data presented as n (%). Genotypic and allelic frequencies of the 1298 A>C and 677 C>T 5,10-methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in rheumatoid arthritis (RA) patients with (+) or without (-) cardiovascular events in the whole cohort and in patients with 10 years follow up. Ref., reference.