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Table 3 Frequencies of gene polymorphisms with or without cardiovascular events: 10 years follow up

From: A1298C polymorphism in the MTHFRgene predisposes to cardiovascular risk in rheumatoid arthritis

  Cardiovascular event occurrence in RA patients
  Overall 10 years follow up
  + - P value + - P value
MTHFR 1298 A>C (n = 77) (n = 511)   (n = 64) (n = 335)  
   AA 29 (37.7) 257 (50.3) Ref. 22 (34.4) 160 (47.8) Ref.
   AC 36 (46.8) 206 (40.3) 0.10 30 (46.9) 142 (42.4) 0.15
   CC 12 (15.6) 48 (9.4) 0.03 12 (18.8) 33 (9.9) 0.01
   A 94 (61.0) 720 (70.5) Ref. 74 (57.8) 462 (69.0) Ref.
   C 60 (39.0) 302 (29.5) 0.02 54 (42.2) 208 (31.0) 0.01
MTHFR 677 C>T (n = 76) (n = 523)   (n = 63) (n = 347)  
   CC 38 (50.0) 219 (41.9) Ref. 31 (49.2) 152 (43.8) Ref.
   CT 28 (36.8) 247 (47.2) 0.11 24 (38.1) 153 (44.1) 0.37
   TT 10 (13.2) 57 (10.9) 0.98 8 (12.7) 42 (12.1) 0.87
   C 104 (68.4) 685 (65.5) Ref. 86 (68.3) 457 (65.9) Ref.
   T 48 (31.6) 361 (34.5) 0.48 40 (31.7) 237 (34.1) 0.64
  1. Data presented as n (%). Genotypic and allelic frequencies of the 1298 A>C and 677 C>T 5,10-methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in rheumatoid arthritis (RA) patients with (+) or without (-) cardiovascular events in the whole cohort and in patients with 10 years follow up. Ref., reference.