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Table 2 Relationship of relDAS28 and single-nucleotide polymorphism genotypes and comparison of allele frequencies between responders and non-responders

From: Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study

Single-nucleotide polymorphisms Pvalue of relDAS28 MAF of responders, percentage (n/N) MAF of non-responders, percentage (n/N) ORa(95% CI) Pvalue
rs983332 0.6 25.9 (30/116) 27.9 (19/68) 1.11 (0.6-2.0) 0.8
rs928655 0.1 18.9 (23/122) 28.0 (19/68) 0.60 (0.3-1.2) 0.1
rs13393173 0.8 23.8 (29/122) 20.6 (14/68) 0.83 (0.4-1.7) 0.6
rs437943 0.05 38.5 (47/122) 25.0 (17/68) 0.53 (0.3-1.0) 0.06
rs10945919 0.7 27.9 (34/122) 23.5 (16/68) 0.79 (0.4-1.7) 0.5
rs854547 0.3 39.3 (48/122) 36.8 (25/68) 1.12 (0.6-2.1) 0.7
rs854548 0.9 23.0 (28/122) 23.5 (16/68) 1.03 (0.5-2.0) 0.9
rs854555 0.6 35.2 (43/122) 38.2 (26/68) 1.14 (0.6-2.0) 0.7
rs868856 0.6 32.8 (40/122) 36.8 (25/68) 1.19 (0.6-2.0) 0.6
rs7046653 0.5 32.0 (39/122) 36.8 (25/68) 1.23 (0.7-2.5) 0.5
rs2814707 0.8 25.4 (31/122) 29.4 (20/68) 1.22 (0.6-2.5) 0.6
rs3849942 0.4 23.0 (28/122) 29.4 (20/68) 1.41 (0.7-2.5) 0.3
rs774359 0.2 26.2 (32/122) 36.8 (25/68) 1.64 (0.8-3.3) 0.1
rs6138150 0.5 14.0 (17/122) 14.7 (10/68) 0.94 (0.4-2.2) 0.9
rs6028945 0.9 12.3 (15/122) 13.2 (9/68) 1.09 (0.5-2.5) 0.9
rs6071980 0.9 18.9 (23/122) 16.2 (11/68) 0.83 (0.4-2.0) 0.6
  1. aOdds ratios (ORs) were calculated as in Liu and colleagues [7], taking the allele associated with the non-responders in that report as the numerator of the odds, and the non-responder odds as the numerator of the OR. CI, confidence interval; MAF, minor allele frequency; n, number of minor alleles; N, total number of alleles; relDAS28, relative change in disease activity score using 28 joint counts between baseline and time of evaluation.