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Table 2 Relationship of relDAS28 and single-nucleotide polymorphism genotypes and comparison of allele frequencies between responders and non-responders

From: Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study

Single-nucleotide polymorphisms

Pvalue of relDAS28

MAF of responders, percentage (n/N)

MAF of non-responders, percentage (n/N)

ORa(95% CI)

Pvalue

rs983332

0.6

25.9 (30/116)

27.9 (19/68)

1.11 (0.6-2.0)

0.8

rs928655

0.1

18.9 (23/122)

28.0 (19/68)

0.60 (0.3-1.2)

0.1

rs13393173

0.8

23.8 (29/122)

20.6 (14/68)

0.83 (0.4-1.7)

0.6

rs437943

0.05

38.5 (47/122)

25.0 (17/68)

0.53 (0.3-1.0)

0.06

rs10945919

0.7

27.9 (34/122)

23.5 (16/68)

0.79 (0.4-1.7)

0.5

rs854547

0.3

39.3 (48/122)

36.8 (25/68)

1.12 (0.6-2.1)

0.7

rs854548

0.9

23.0 (28/122)

23.5 (16/68)

1.03 (0.5-2.0)

0.9

rs854555

0.6

35.2 (43/122)

38.2 (26/68)

1.14 (0.6-2.0)

0.7

rs868856

0.6

32.8 (40/122)

36.8 (25/68)

1.19 (0.6-2.0)

0.6

rs7046653

0.5

32.0 (39/122)

36.8 (25/68)

1.23 (0.7-2.5)

0.5

rs2814707

0.8

25.4 (31/122)

29.4 (20/68)

1.22 (0.6-2.5)

0.6

rs3849942

0.4

23.0 (28/122)

29.4 (20/68)

1.41 (0.7-2.5)

0.3

rs774359

0.2

26.2 (32/122)

36.8 (25/68)

1.64 (0.8-3.3)

0.1

rs6138150

0.5

14.0 (17/122)

14.7 (10/68)

0.94 (0.4-2.2)

0.9

rs6028945

0.9

12.3 (15/122)

13.2 (9/68)

1.09 (0.5-2.5)

0.9

rs6071980

0.9

18.9 (23/122)

16.2 (11/68)

0.83 (0.4-2.0)

0.6

  1. aOdds ratios (ORs) were calculated as in Liu and colleagues [7], taking the allele associated with the non-responders in that report as the numerator of the odds, and the non-responder odds as the numerator of the OR. CI, confidence interval; MAF, minor allele frequency; n, number of minor alleles; N, total number of alleles; relDAS28, relative change in disease activity score using 28 joint counts between baseline and time of evaluation.