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Figure 7 | Arthritis Research & Therapy

Figure 7

From: Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts

Figure 7

Bortezomib overrides the effect of TGF-β and imposes its anti-fibrotic activity. Schematic representation of the effect of bortezomib (left), TGF-β (middle), and bortezomib plus TGF-β (right) on transcription of the MMP-1, COL1A1, and COL1A2 genes. See the Discussion section of the text for details. Bor, bortezomib; COL1A, collagen 1A; MMP-1, matrix metalloproteinase-1; TGF-β, transforming growth factor-beta.

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