Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment

Table 4 Clinical course of disease 2

Symptom	0 months	1 month	3 months	6 months	12 months	Mean in first year
Severity of disease - physician	5.0	2.4^a	1.4^a	1.1^a,b	0.6^a,b,c	2.1
Severity of disease - patient	4.7	1.5^a	1.1^a	0.8^a	0.7^a,b	1.8
Pain	4.4	1.5^a	0.8^a	0.8^a	0.6^a	1.6
Global assessment/CHAQ	3.8	1.4^a	0.8^a	0.8^a	0.5^a	1.5
CHAQ score	0.7	0.3^a	0.1^a	0.1^a,b	0^a,b	0.7

Results presented as mean. Statistical analysis performed using analysis of variance. CHAQ, childhood health assessment questionnaire. ^aP < 0.05 versus month 0. ^bP < 0.05 versus month 1. ^cP < 0.05 versus month 2.

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