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Table 2 Logistic regression analysis exploring the relationship between anti-CCP/IgM RF and persistent arthritic disease

From: The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis

  Univariate Multivariate*
  estimate OR
(95% CI)
P estimate OR
(95% CI)
P
Anti-CCP2
(units/ml)
0.013 1.013
(1.008 to 1.018)
<0.001 0.008 1.008
(1.003 to 1.013)
0.002
Anti-CCP2+
(>25 units/ml)
2.102 8.184
(4.008 to 16.709)
<0.001 1.272 3.567
(1.572 to 8.094)
0.002
IgM RF (units/ml) 0.022 1.022
(1.012 to 1.033)
<0.001 0.009 1.009
(1.001 to 1.017)
0.026
IgM RF+ (>25 units/ml) 2.018 7.526
(3.677 to 15.407)
<0.001 0.999 2.716
(1.189 to 6.202)
0.018
IgM RF+ and anti-CCP+ 2.593 13.369
(4.658 to 38.369)
<0.001 2.073 7.948
(2.659 to 23.752)
<0.001
  1. *Adjusted for age, sex, small joint arthritis (swelling of MTP-, PIP- and/or MCP joints), Health Assessment Questionnaire, 28-tender joint count, C-reactive protein (mg/l), morning stiffness >1 hour, as well as IgM rheumatoid factor (for the analysis with anti-CCP) or anti-CCP (for the analysis with IgM RF), respectively.