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Table 4 Sensitivity, specificity, and likelihood ratios for persistent arthritis for different minimum cut-off levels for anti-CCP2 and IgM RF

From: The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis

Cut-off anti-CCP2
(units/ml)
Sensitivity Specificity Accuracy LR+
(95% CI)
LR-
(95% CI)
2 0.71 0.55 0.63 1.59 (1.32 to 1.91) 0.53 (0.41 to 0.69)
3 0.58 0.72 0.65 2.06 (1.60 to 2.65) 0.58 (0.48 to 0.71)
4 0.47 0.80 0.65 2.38 (1.73 to 3.27) 0.66 (0.56 to 0.77)
5 0.43 0.87 0.67 3.23 (2.18 to 4.77) 0.66 (0.57 to 0.77)
10 0.35 0.93 0.66 4.98 (2.88 to 8.58) 0.71 (0.69 to 1.79)
15 0.32 0.95 0.66 5.91 (3.20 to 10.92) 0.72 (0.64 to 0.80)
20 0.31 0.95 0.65 5.59 (3.02 to 10.37) 0.74 (0.66 to 0.82)
25 0.30 0.95 0.64 6.04 (3.17 to 11.51) 0.74 (0.67 to 0.82)
Cut-off IgM RF
(units/ml)
Sensitivity Specificity Accuracy LR+ LR-
2 0.71 0.41 0.55 1.20 (1.04 to 1.39) 0.71 (0.53 to 0.94)
3 0.62 0.54 0.58 1.34 (1.13 to 1.65) 0.70 (0.55 to 0.88)
5 0.51 0.69 0.61 1.67 (1.30 to 2.15) 0.71 (0.59 to 0.84)
7 0.43 0.77 0.61 1.85 (1.37 to 2.51) 0.74 (0.64 to 0.86)
10 0.33 0.87 0.62 2.49 (1.66 to 3.76) 0.77 (0.68 to 0.87)
15 0.31 0.92 0.64 3.69 (2.22 to 6.12) 0.75 (0.68 to 0.84)
20 0.29 0.95 0.64 5.28 (2.84 to 9.81) 0.75 (0.68 to 0.83)
25 0.28 0.95 0.64 5.69 (2.97 to 10.89) 0.76 (0.69 to 0.83)
  1. CI: confidence interval; LR+: positive likelihood ratio; LR-: negative likelihood ratio.