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Table 1 Baseline characteristics of patients

From: Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease

Feature MCTDa Controls Pvalue, MCTD vs. controls MCTDb CVD+ MCTD CVD- Pvalue, MCTD/CVD+ vs. MCTD/CVD-
n 50 38   23 27  
Age at investigation (years) 50.2 ± 10.0 50.4 ± 10.3 0.936 50.1 ± 10.7 50.2 ± 9.5 0.99
Disease duration (years) 9.56 ± 6.8 (3 to 26) - - 10.3 ± 6.6 (3 to 26) 8.9 ± 6.9 (3 to 25) 0.481
SBP (mmHg) 137.4 ± 21.1 132.9 ± 19.6 0.367 144.7 ± 19.5 131.1 ± 20.6 0.037
DBP (mmHg) 90.9 ± 15.9 86.6 ± 15.3 0.215 88.5 ± 14.9 92.9 ± 16.8 0.299
BMI (kg/m2) 24.2 ± 1.3 23.2 ± 1.1 0.77 23.9 ± 1.1 24.81.9 0.383
Smoking       
   Former smokers 5 (10%) 5 (13.1) 0.7401 2 (8.6) 3 (11.1) 1.0
   Nonsmokers 45 (90%) 33 (86.8%) 0.7401 21 (91.3) 24 (88.8) 1.0
Serum triglyceride (mmol/l) 1.611 ± 0.76 1.6 ± 0.79 0.755 1.5 ± 0.82 1.72 ± 0.70 0.3367
Total cholesterol (mmol/l) 5.94 ± 1.18 5.47 ± 1.03 0.047 5.8 ± 1.2 6.06 ± 1.13 0.108
HDL-C (mmol/l) 1.69 ± 0.5 1.68 ± 0.49 0.943 1.56 ± 0.48 1.8 ± 0.5 0.22
LDL-C (mmol/l) 3.62 ± 1.15 3.23 ± 0.88 0.148 3.52 ± 1.19 3.7 ± 1.12 0.333
ApoA1 (g/l) 1.31 ± 0.36 1.72 ± 0.47 <0.001 1.27 ± 0.3 1.33 ± 0.4 0.003
ApoB (g/l) 0.95 ± 0.31 0.91 ± 0.13 0.693 0.98 ± 0.38 0.89 ± 0.15 0.92
Paraoxonase-1 activity 113.6 ± 70.6 187.4 ± 68.3 <0.001 84.32 ± 69.66 138.7 ± 62.3 <0.001
hs-CRP (mg/l) 15.2 ± 9.62 1.44 ± 0.99 <0.001 22.1 ± 9.78 9.36 ± 3.96 <0.001
ESR (mm/hour) 20.2 ± 17.8 8.3 ± 3.9 <0.001 26.5 ± 17.6 14.4 ± 16.2 0.014
  1. ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; BMI, body mass index; CVD, cardiovascular disease; DBP, diastolic blood pressure; ESR: erythrocyte sedimentation rate; HDL-C, high-density lipoprotein-cholesterol; hs-CRP: high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein-cholesterol; MCTD, mixed connective tissue disease; SBP, systolic blood pressure. aMann-Whitney U test. bKruskal-Wallis analysis of variance.
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