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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Natural killer cells control a T-helper 1 response in patients with Behçet's disease

Figure 5

Natural killer cell suppression of IFNγ expression by T-helper 1 cells in inactive Behçet's disease. Suppression of IFNγ expression in T-helper 1 (Th1) cells by cell-contact-free co-culture with natural killer (NK) type 2 cells from inactive Behçet's disease (iBD) patients. T cells from active Behçet's disease patients were cultured alone or in combination with NK cells from healthy controls or iBD patients, and the IFNγ expression level in the CD4+ T cells was evaluated using flow cytometry. (a) Representative histogram plots showing expression of IFNγ on gated CD4+ T cells that were cultured alone, or with NK cells from an iBD patient or a healthy control. Vertical line in each histogram indicates the median. (b) IFNγ expression levels in Th1 cells cultured with the NK cells from six iBD patients or from five healthy controls. Relative IFNγ expression level calculated as the ratio of IFNγ expression by CD4+ T cells cultured with NK cells to the expression by CD4+ T cells cultured alone. Horizontal bars, mean values.

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