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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Altered microRNA expression profile with miR-146a upregulation in CD4+T cells from patients with rheumatoid arthritis

Figure 4

Gene expression profiles in Jurkat T cells with up-regulated and down-regulated miR-146a expression. (a) Schematic representation of FUGW-miR-146a sponge, which was inserted into lentivirus vector FUGW. (b) Gene expression profiles of Jurkat T cells transfected with FUGW-miR-146a or FUGW-miR-146a sponge were analyzed by Affymetrix GeneChip. Fas-associated factor 1 (FAF1) was found to be negatively correlated to the level of miR-146a. (c) Expression levels of FAF1 were further verified by quantitative RT-PCR, consistent with the results from gene chip analysis. FUGW-FF3-Jurkat T cells were used as the control. The value of each control sample was set at one and further used to calculate the fold change.

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