Table 1 Genes, that are differentially expressed during cell culture
Gene group | Regulated genes | RA-1 | RA-2 | RA-3 | RA-4 | ||||
|---|---|---|---|---|---|---|---|---|---|
Cytokines/-receptors | TNF receptor 1 | 3 | ↓ | 5-8 | ↑ | 5 | ↑ | 3-8 | ↑ |
MCSF I receptor precursor | 6,8 | ↑ | 6-8 | ↓ | 2 | ↓ | 5-8 | ↓ | |
epidermal growth factor receptor 1 | 3,4 | ↑ | - | 6-8 | ↑ | 4-8 | ↑ | ||
insulin-like growth factor I receptor | >5 | ↑ | 3,7 | ↑ | 7-8 | ↑ | 5,6,8 | ↑ | |
Adhesion | ILK | >5 | ↓ | 2 | ↑ | 2,6 | ↑↓ | 4-8 | ↓ |
Apoptosis | Fas-activated serine/threonine kinase cytotoxic TRAIL receptor 2 (DR 5) | 4-8 | ↑ | 7-8 | ↑ | 6 | ↑ | 6-8 | ↑ |
5-8 | ↑ | 2 | ↓ | 7-8 | ↓ | 8 | ↑ | ||
Proliferation | tumor suppressor LUCA1 | 6-8 | ↑ | 7-8 | ↑ | 7-8 | ↑ | 6,8 | ↑ |
p33ING1 | 4-8 | ↑ | 6-8 | ↑ | 3-8 | ↑ | 3-8 | ↑ | |
p53 cellular tumor antigen | 4-8 | ↑ | 6,8 | ↑ | 3,7 | ↑ | 7-8 | ↑ | |
cyclin-dependent kinase inhibitor 1C | 6-8 | ↑ | 2 | ↑ | 4-8 | ↑ | - | ||
ski oncogene | 7-8 | ↑ | 4 | ↑ | 6,7 | ↑ | 6,8 | ↑ | |
Proliferation/Signaling | shb proto-oncogene | 4-8 | ↓ | 7-8 | ↓ | - | 2 | ↓ | |
Signaling | notch2 | 5-8 | ↑ | 6 | ↑ | 5,6,8 | ↑ | 5 | ↑ |
jun-B | 7-8 | ↑ | 4,5,7,8 | ↑ | 5-8 | ↑ | 4,7 | ↑ | |
frizzled | 7-8 | ↑ | 8 | ↑ | 2 | ↑ | 8 | ↓ | |
FRA2 | 3-8 | ↓ | 7-8 | ↓ | 5-7 | ↓ | 2 | ↑ | |
NOTCH1 precursor | 5-8 | ↑ | 5 | ↑ | 4,5 | ↑ | 7-8 | ↑ | |
Others | semaphorin 1 | 7-8 | ↑ | - | 4-8 | ↓ | 3,4 | ↑ | |
glycogen synthase kinase 3 alpha | 6-8 | ↑ | 6 | ↑ | 5-8 | ↑ | 3-8 | ↑ | |
thymosin beta-10 | 5,6,8 | ↓ | 4,6,7 | ↓ | 7-8 | ↑ | 5-8 | ↑ | |
ezrin; cytovillin 2; VIL2 | 7-8 | ↓ | 4-8 | ↓ | 4 | ↑ | 5 | ↓ | |