Figure 3

The concentrations of miRNAs in the condition medium of each cell or tissue of RA and OA. A, FLSs of RA (n = 4) and OA (n = 5) were cultured in serum-free medium for 48 h. Concentrations of miRNAs in each conditioned medium are shown. B, Synovial tissues of RA (n = 3) and OA (n = 3) were cultured in serum-free medium for 48 h. Concentrations of miRNAs in conditioned medium are shown. There were no statistically significant differences between RA and OA in A and B. C, PB MNCs of RA (n = 3), OA (n = 3) and HC (n = 3) were cultured in serum-free medium for 48 h. Concentrations of each miRNA in conditioned medium are shown. There were no statistically significant differences among RA, OA and HC. D, Radar charts show the average concentrations of each miRNA of each sample. Expression patterns of plasma miRNA of RA and OA were similar. Synovial fluid miRNAs were similar to the miRNAs secreted by synovial tissues.