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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Inhibitor of IκB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells

Figure 4

BAY11 does not affect poly IC-induced IFN-α production. Human myeloid DCs were pretreated for 15 minutes with different concentrations of BAY11 (10-9, 3 × 10-9, 10-8, 3 × 10-8, 10-7, 3 × 10-7) or vehicle, followed by addition of 10 μg/ml poly IC. After 24 hours, the concentrations of IFN-α, TNF-α and IL-12 in the culture supernatants were measured by ELISA. Data are shown as mean ± SEM of four independent donors. Statistical significance was determined using Mann-Whitney test (*P < 0.05, **P < 0.01).

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Arthritis Research & Therapy

ISSN: 1478-6362

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