Figure 5

Administration of ZSTK474 inhibited in vivo OC formation and bone resorption in CIA mice. a) The synovial sections described above were stained with H&E and also with TRAP to examine in vivo OC formation. Representative results are shown. b) Plasma levels of TRACP5b were measured. The levels of TRACP5b in vehicle- 25 mg/kg, and 50 mg/kg ZSTK474-treated mice, but not 100 mg/kg ZSTK474-treated mice, were significantly raised in comparison with that of intact mice (*P < 0.05, **P < 0.01).