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Table 2 Associations between hip JSN and serum leptin or IL-6 levels

From: The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study

 

Univariable

Multivariablea

Multivariableb

 

β (CI)

P

β (CI)

P

β (CI)

P

Leptin (grade per μg/L)

      

   superior JSN

      

   Male

0.063 (-0.005 to 0.131)

0.070

0.060 (-0.012 to 0.132)

0.100

0.056 (-0.019 to 0.132)

0.145

   Female

0.046 (0.021 to 0.071)

<0.001

0.043 (0.004 to 0.083)

0.030

0.038 (-0.001 to 0.078)

0.057

   Both sexes

0.047 (0.026 to 0.069)

<0.001

0.046 (0.006 to 0.086)

0.024

0.041 (0.000 to 0.082)

0.051

   Axial JSN

      

   Male

0.051 (-0.024 to 0.126)

0.182

0.081 (0.007 to 0.154)

0.031

0.077 (-0.002 to 0.155)

0.055

   Female

0.041 (0.016 to 0.066)

0.002

0.066 (0.017 to 0.115)

0.008

0.060 (0.011 to 0.109)

0.017

   Both sexes

0.052 (0.029 to 0.074)

<0.001

0.068 (0.022 to 0.115)

0.004

0.063 (0.014 to 0.112)

0.012

IL-6 (grade per pg/ml)

      

   Superior JSN

      

   Male

-0.055 (-0.260 to 0.151)

0.603

-0.066 (-0.268 to 0.136)

0.524

-0.062 (-0.270 to 0.146)

0.556

   Female

0.257 (0.115 to 0.400)

<0.001

0.241 (0.087 to 0.394)

0.002

0.202 (0.044 to 0.360)

0.012

   Both sexes

0.124 (-0.020 to 0.267)

0.092

0.101 (-0.042 to 0.243)

0.166

0.079 (-0.070 to 0.228)

0.297

   Axial JSN

      

   Male

-0.136 (-0.420 to 0.148)

0.349

-0.138 (-0.409 to 0.134)

0.321

-0.166 (-0.418 to 0.086)

0.197

   Female

0.212 (0.085 to 0.338)

0.001

0.239 (0.101 to 0.377)

0.001

0.199 (0.057 to 0.341)

0.006

   Both sexes

0.103 (-0.025 to 0.230)

0.116

0.112 (-0.010 to 0.233)

0.071

0.073 (-0.056 to 0.201)

0.267

  1. aAdjusted for age, sex if both sexes, BMI, ever smoked, diabetes, rheumatoid arthritis, heart disease, and asthma. bFurther adjusted for leptin if IL-6, or IL-6 if leptin. Dependent variable, JSN grade (0-2) in superior or axial compartment. Independent variable, serum level of leptin (μg/L) or IL-6 (pg/ml). IL-6, interleukin-6; CI, confidence interval; JSN, joint-space narrowing; BMI, body mass index.