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Table 2 Associations between hip JSN and serum leptin or IL-6 levels

From: The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study

  Univariable Multivariablea Multivariableb
  β (CI) P β (CI) P β (CI) P
Leptin (grade per μg/L)       
   superior JSN       
   Male 0.063 (-0.005 to 0.131) 0.070 0.060 (-0.012 to 0.132) 0.100 0.056 (-0.019 to 0.132) 0.145
   Female 0.046 (0.021 to 0.071) <0.001 0.043 (0.004 to 0.083) 0.030 0.038 (-0.001 to 0.078) 0.057
   Both sexes 0.047 (0.026 to 0.069) <0.001 0.046 (0.006 to 0.086) 0.024 0.041 (0.000 to 0.082) 0.051
   Axial JSN       
   Male 0.051 (-0.024 to 0.126) 0.182 0.081 (0.007 to 0.154) 0.031 0.077 (-0.002 to 0.155) 0.055
   Female 0.041 (0.016 to 0.066) 0.002 0.066 (0.017 to 0.115) 0.008 0.060 (0.011 to 0.109) 0.017
   Both sexes 0.052 (0.029 to 0.074) <0.001 0.068 (0.022 to 0.115) 0.004 0.063 (0.014 to 0.112) 0.012
IL-6 (grade per pg/ml)       
   Superior JSN       
   Male -0.055 (-0.260 to 0.151) 0.603 -0.066 (-0.268 to 0.136) 0.524 -0.062 (-0.270 to 0.146) 0.556
   Female 0.257 (0.115 to 0.400) <0.001 0.241 (0.087 to 0.394) 0.002 0.202 (0.044 to 0.360) 0.012
   Both sexes 0.124 (-0.020 to 0.267) 0.092 0.101 (-0.042 to 0.243) 0.166 0.079 (-0.070 to 0.228) 0.297
   Axial JSN       
   Male -0.136 (-0.420 to 0.148) 0.349 -0.138 (-0.409 to 0.134) 0.321 -0.166 (-0.418 to 0.086) 0.197
   Female 0.212 (0.085 to 0.338) 0.001 0.239 (0.101 to 0.377) 0.001 0.199 (0.057 to 0.341) 0.006
   Both sexes 0.103 (-0.025 to 0.230) 0.116 0.112 (-0.010 to 0.233) 0.071 0.073 (-0.056 to 0.201) 0.267
  1. aAdjusted for age, sex if both sexes, BMI, ever smoked, diabetes, rheumatoid arthritis, heart disease, and asthma. bFurther adjusted for leptin if IL-6, or IL-6 if leptin. Dependent variable, JSN grade (0-2) in superior or axial compartment. Independent variable, serum level of leptin (μg/L) or IL-6 (pg/ml). IL-6, interleukin-6; CI, confidence interval; JSN, joint-space narrowing; BMI, body mass index.