The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study

Table 4 Associations between body composition and hip JSN in men

	Multivariable^a		Multivariable^b		Multivariable^c
	β (CI)	P	β (CI)	P	β (CI)	P
Superior JSN
BMI (grade per kg/m²)	0.10 (0.00 to 0.21)	0.061	0.06 (-0.04 to 0.17)	0.242	0.10 (0.00 to 0.20)	0.058
WHR (grade per 100%)	1.99 (-5.49 to 9.48)	0.602	0.64 (-6.52 to 7.80)	0.861	1.82 (-5.68 to 9.31)	0.635
Trunk fat (grade per 100%)	2.40 (-6.75 to 11.56)	0.607	1.31 (-7.52 to 10.14)	0.771	2.42 (-6.86 to 11.70)	0.609
Total fat (grade per 100%)	2.32 (-10.03 to 14.67)	0.713	-0.12 (-11.69 to 11.45)	0.983	2.30 (-10.24 to 14.84)	0.719
Axial JSN
BMI (grade per kg/m²)	0.09 (-0.04 to 0.22)	0.165	0.02 (-0.09 to 0.13)	0.750	0.09 (-0.03 to 0.21)	0.150
WHR (grade per 100%)	2.29 (-7.66 to 12.25)	0.652	-0.41 (9.77 to 8.96)	0.932	1.94 (-7.88 to 11.75)	0.699
Trunk fat (grade per 100%)	0.08 (-11.25 to 11.42)	0.988	-1.87 (-11.26 to 7.52)	0.697	-0.41 (-12.19 to 11.37)	0.945
Total fat (grade per 100%)	-3.45 (-18.94 to 12.04)	0.662	-6.16 (-18.76 to 6.45)	0.338	-4.25 (-20.71 to 12.22)	0.613

^aAdjusted for age, height, ever smoked, diabetes, rheumatoid arthritis, heart disease, and asthma. ^bFurther adjusted for leptin or ^cfurther adjusted for interleukin-6. Dependent variable, JSN grade (0-2) in superior or axial compartment. Independent variable, BMI, WHR, trunk fat, or total fat (all except BMI expressed as percentages between 0 and 100%). IL-6, interleukin-6; CI, confidence interval; JSN, joint-space narrowing; BMI, body mass index; WHR, waist-to-hip ratio.

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