Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis

Table 4 Baseline and one-year follow-up predictors, progressive SHS of 5 units or more in the first year excluded, of subsequent progressive total joint damage in hands and feet after four years derived from multivariate logistic regression analysis

	Progressive joint damage 1-4 ≥ 5 units
	β	OR (95% CI)	Pvalue
Baseline variables
Presence ACPA	1.30	3.95 (1.17-15.0)	0.017
Presence RF	0.11	1.10 (0.38-2.98)	0.803
SHS ≥ 1 unit	1.81	5.78 (1.23-28.1)	0.020
First year follow-up variables
High AUC ESR	0.002	1.002 (0.999-1.004)	0.160
High AUC CRP	0.002	1.002 (1.000-1.004)	0.059
Progressive SHS ≥ 5 units	-	-	-
Hand BMD loss >0.003 g/cm²	1.10	3.00 (1.12-8.81)	0.035
R², adjusted		0.290

All variables with a P < 0.10 in the univariate analyses, except progression SHS of 5 units or more in the first year, were entered in this multivariate analysis corrected for age, gender, postmenopausal status, BMI and health assessment questionnaire and first year follow-up variables additionally corrected for the use of anti-resorptive therapy (bisphosphonates, calcium and vitamin D suppletion and hormone replacement therapy) and intraarticular corticosteroid injections during first year and treatment group during.
ACPA, anti-citrullinated protein antibodies; AUC, area under the curve; BMD, bone mineral density; BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; OR, odds ratio; RF, rheumatoid factor; SHS, Sharp-van der Heijde score.

ISSN: 1478-6362