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Table 4 Relationship between time-to-remission and sustained remission

From: Time to achieve remission determines time to be in remission

  All patients (n = 753) 1985-1990
(n = 147)
1991-1995
(n = 158)
1996-2000
(n = 219)
2001-2005
(n = 229)
DAS remission      
Achieving remission (n [%]) 1 398 [53%] 77 [52%] 68 [43%] 124 [57%] 129 [56%]
Time-to-remission
(median [IQR], months)
33
[11-36]
35
[14-36]
36
[12-36]
28
[9-36]
26
[9-36]
Sustained remission (n [%]) 2 142 [36%] 22 [29%] 25 [37%] 46 [37%] 49 [38%]
Time in sustained remission
(median [IQR], months])
19
[10-28]
9
[6-22]
22
[14-29]
18
[10-26]
22
[13-29]
Relationship between time to
achieve and sustained remission
(OR [95%CI]) 3
1.11
[1.10-1.12]
1.09
[1.07-1.11]
1.15
[1.12-1.17]
1.09
[1.08-1.11]
1.13
[1.11-1.15]
mACR remission      
Achieving remission (n [%]) 4 226 [30%] 48 [33%] 45 [29%] 62 [28%] 71 [31%]
Time-to-remission
(median [IQR], months)
13
[8-24]
15
[10-28]
13
[7-24]
15
[9-23]
10
[7-19]
Sustained remission (n [%]) 5 58 [26%] 8 [17%] 18 [33%] 13 [21%] 19 [27%]
Time in sustained remission
(median [IQR], months])
10
[6-16]
7
[6-8]
11
[7-16]
7
[6-16]
13
[7-24]
Relationship between time to
achieve and sustained remission
(OR [95%CI]) 3
1.15
[1.14-1.16]
1.13
[1.09-1.16]
1.12
[1.07-1.18]
1.08
[0.96-1.22]
1.12
[0.93-1.16]
  1. 1 Number of patients achieving at least one period of remission (disease activity score, DAS<1.6) during 3 years follow-up. 2 Number of patients who had sustained DAS remission (6 months or more) during 3 years follow-up. 3 Odds ratios (ORs) of remission during 3 years follow-up analyzed by longitudinal binary regression with remission status over time as dependent variable, time-to-remission (months) and DAS value of the previous visit as main covariates. 4 Number of patients achieving at least one period of remission (modified American College of Rheumatology, mACR) during 3 years follow-up. Fulfillment of the mACR remission criteria was based on 4 of the following 5 criteria to be met: 1) morning stiffness ≤ 15 minutes, 2) VAS pain ≤ 10 mm, 3) no tender joints (out of 53 joints), 4) no swollen joints (out of 44 joints), and 5) ESR < 30 mm/h (female) or < 20 mm/h (male). 5 Number of patients who had sustained mACR remission (6 months or more) during 3 years follow-up. IQR = interquartile range, P25-P75; CI = confidence interval.