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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis

Figure 2

Histology of treated and untreated collagen antibody-induced arthritis mice. (a) Collagen antibody-induced arthritis (CAIA)/vehicle mouse interphalangeal joint (10× magnification) showing expansion of synovial and extraarticular tissues, as well as the joint spaces, by edema and inflammatory cell infiltrates (asterisks). Inset: higher magnification (40×) view of osteoclast-mediated bone resorption (arrow). (b) Prednisolone-treated mouse interphalangeal joint (10× magnification) with normal synovial tissue and cartilage. Inset: high magnification view (40×) showing absence of bone resorption. (c) Celecoxib-treated mouse interphalangeal joint (10× magnification) also with inflammatory cells in the joint capsule, synovium, and joint space (asterisks). Inset: higher magnification (40×) view of osteoclast-mediated bone resorption (arrow). (d) p38 mitogen-activated protein kinase (MAPK) inhibitor-treated mouse interphalangeal joint (10× magnification) with mildly decreased edema and inflammation in the joint space (asterisks) as compared with vehicle and celecoxib groups. Inset: higher magnification (40×) view showing inflammation (arrow) but minimal apparent osteoclast-mediated bone resorption. Histology assessment is representative of two separate experiments.

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