Figure 3

Histopathology scoring. Hindpaw tissues (n = 12 per group, one paw from each mouse) from the study represented in Figure 1 were processed for histopathology assessment. (a) Histopathology severity scores for general inflammation. (b) Histopathology severity scores for cartilage damage. (c) Histopathology severity scores for osteoclast-mediated bone resorption. Histology scoring results are representative of two separate experiments. *P < 0.01, **P < 0.001; ns, not significant. MAPKi, mitogen-activated protein kinase inhibitor.