Figure 4

Plasma biomarker measurement. Day 8, peak disease plasma samples from the study represented in Figure 1 (n = 12 per group) were analyzed for a variety of biomarker changes as described in Materials and methods. (a) Quantification of plasma eotaxin levels. (b) Quantification of IL-6 levels. (c) Quantification of granulocyte colony-stimulating factor (G-CSF) levels. (d) Quantification of matrix metalloproteinase MMP-3 levels. ^#P < 0.05, *P < 0.01, **P < 0.001; ns, not significant. MAPKi, mitogen-activated protein kinase inhibitor.