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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis

Figure 5

Tomographic imaging of arthritis in collagen antibody-induced arthritis mice. Arthritic and control BALB/c mice (n = 12 mice per group) were injected intravenously with ProSense750 on day 7 and imaged by FMT2500™ using tomographic scanning capabilities. (a) Near-infrared (NIR) tomographic imaging of the hind paws of a BALB/c control mouse. (b) NIR tomographic imaging of the hind paws of an arthritic collagen antibody-induced arthritis (CAIA) mouse with 1 mm tomographic slices shown from the right paw. (c) Quantification of tomographic hind paw fluorescence (picomoles) divided by ankle, midfoot, and toes of arthritic and control mice (n = 12 per group). Study is representative of three separate experiments. **P < 0.001.

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Arthritis Research & Therapy

ISSN: 1478-6362

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