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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis

Figure 6

Near-infrared tomographic slices showing protease activity in paws of arthritic and treated mice. Representative paws of mice from each of the groups of the study represented in Figure 1 (that is, selected paws at or near the group mean) were analyzed at the level of individual tomographic slices to determine the pattern of fluorescence signal in the ankle, mid-foot, and toe region for each mouse. Color scale represents local regions of fluorescence intensity (nanomolar) concentration. (a) Axial tomographic slices of fluorescence resulting from local cathepsin activity. (b) Axial tomographic slices of fluorescence resulting from local matrix metalloprotease (MMP) activity. COX-2i, cyclooxygenase-2 inhibitor; MAPKi, mitogen-activated protein kinase inhibitor.

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