Figure 7

Near-infrared tomographic quantification of paw subregions of arthritic and treated mice. Each individual paw (n = 24 per group) from the study represented in Figure 1 was analyzed to quantify the fluorescence signal in the ankle, mid-foot, and toe region for each mouse. (a) Tomographic quantification of regional fluorescence resulting from cathepsin activity. (b) Tomographic quantification of regional fluorescence resulting from local matrix metalloprotease (MMP) activity. Analysis representative of six studies using a variety of imaging agents. **P < 0.001. MAPKi, mitogen-activated protein kinase inhibitor.