Figure 8

Near-infrared tomography correlation with histology inflammation scoring. The study results from individual paws from each group in the study (n = 12 per group, one paw per animal) represented in Figure 7 (using the total of the paw fluorescence) were sorted according to histology inflammation score (0 to 4), and means of the sorted groups were calculated for clinical score, paw swelling, and fluorescence molecular tomography (FMT) imaging readouts. Correlation with histologic inflammation: (a) total paw cathepsin, (b) total paw matrix metalloprotease (MMP) activity, (c) clinical score, and (d) paw swelling. (e) Non-invasive FMT picomole values were used to predict the pathologist's histology inflammation scores based on the linear relationships between ProSense750 and MMPSense680 to individual paw histology inflammation scores. Results presented as group means ± standard error of the means. MAPKi, mitogen-activated protein kinase inhibitor.