Figure 9

Tomographic imaging of bone changes in collagen antibody-induced arthritis mice. Vehicle, control, and treated mice were injected intravenously with OsteoSense680 on day 7 or day 14 and were imaged by FMT2500™. Quantitation of tomographic hind paw fluorescence (picomoles) of arthritic and control mice (n = 6 per group) is represented for day 8 and day 15 imaging. Study is representative of two separate experiments. ^#P < 0.05, *P < 0.01, **P < 0.001; ns, not significant. MAPKi, mitogen-activated protein kinase inhibitor.