The effect of 25 mg/kg apremilast or rolipram on spontaneous behaviour was tested on naïve mice using LABORAS automated activity monitor. The average time spent (a) immobile and grooming and (b) climbing and during locomotion are plotted. n = 8 per group, * P < 0.05, *** P < 0.001, relative to vehicle treatment. Mice were monitored for 30 minutes, one hour after receiving treatment. n.s., not significant.