Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus

Table 1 Nitric oxide-induced T cell functions in sysemic lupus erythematosus and rheumatoid arthritis

Altered T cell function	SLE	RA
Mitochondrial hyperpolarization and biogenesis	Higher [10]	Normal [27]
Tlymphocyte NO production	Normal [10]	Increased [27]
TCR-induced rapid and sustained Ca²⁺ signal	Rapid-increased, sustained-decreased [10]	Normal [22]
TCR expression	Decreased [34]	Decreased [61]
mTOR activity	Increased [29]	Not known
ATP level	Decreased [28]	Normal [28]
Monocyte NO production	Increased [10]	Increased [46]

mTOR, mammalian target of rapamycin; NO, nitric oxide; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; TCR, T cell antigen receptor.

ISSN: 1478-6362