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Table 1 Nitric oxide-induced T cell functions in sysemic lupus erythematosus and rheumatoid arthritis

From: Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus

Altered T cell function SLE RA
Mitochondrial hyperpolarization and biogenesis Higher [10] Normal [27]
Tlymphocyte NO production Normal [10] Increased [27]
TCR-induced rapid and sustained Ca2+ signal Rapid-increased, sustained-decreased [10] Normal [22]
TCR expression Decreased [34] Decreased [61]
mTOR activity Increased [29] Not known
ATP level Decreased [28] Normal [28]
Monocyte NO production Increased [10] Increased [46]
  1. mTOR, mammalian target of rapamycin; NO, nitric oxide; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; TCR, T cell antigen receptor.