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Table 3 Posttraumatic osteoarthritis: needs, opportunities and challenges

From: New developments in osteoarthritis: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

Therapies needed for posttraumatic inflammation and osteoarthritis prevention

Readily identified population at high risk for osteoarthritis

Pathways and targets identified

Several clinical-stage therapeutic candidates

Therapeutic window immediately following injury

Long latency period until overt structural change

Clinical trials for osteoarthritis prevention depend on surrogate markers