Figure 1From: Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatmentChanges in IgG subclasses after protein and polysaccharide vaccination in rheumatoid arthritis (RA) patients before and after RTX treatment. (a) Changes at day 21 as compared with day 0 in immunoglobulin G (IgG)1-4 are shown after influenza vaccination. (b) Changes at day 21 as compared with day 0 in IgG1-4 after P23 vaccination. In all figure parts, day 0 levels are set at 100%, and day 21 indicates changes relative to day 0. Dotted line indicates cutoff, set at 110%. Each dot corresponds to one patient, and statistical evaluation was performed by using the paired t test; statistical significance is set at P < 0.05. *P < 0.05; **P < 0.01; ***P < 0.0001.Back to article page