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Table 4 Individual responses of total IgG or IgG subclasses after influenza and pneumococcal polysaccharide immunization

From: Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatment

Patients Total IgG IgG1 IgG2 IgG3 IgG4 Total IgG IgG1 IgG2 IgG3 IgG4 Previous RTX
Influenza       P23      
Pre-RTX            
1 176 289 99 125 117 152 95 105 110 115 1
2 a 94 86 98 89 74 102 454 534 203 117 no
3 a 163 128 110 112 111 204 262 107 95 115 no
4 a 154 292 198 178 108 335 77 167 129 148 no
5 a 132 368 99 121 123 217 246 458 128 113 no
Post-RTX            
1a 139 202 123 116 153 151 83 85 95 102 no
2 126 260 133 136 158 110 103 104 95 101 2
3 109 93 115 110 107 107 143 105 107 116 no
4 100 97 89 102 91 102 104 98 111 112 no
5a 115 89 72 100 96 93 87 211 112 108 no
6a 85 93 76 87 102 88 82 187 96 107 3
7 98 82 94 96 97 107 95 94 98 94 no
8 103 99 86 124 113 95 233 257 126 117 no
9a 104 102 115 91 103 126 92 105 92 98 1
10 127 222 115 160 170 104 159 248 175 206 2
11a 134 157 110 119 109 122 167 140 125 144 no
Controls            
1 117 95 84 113 108 213 91 171 89 83 no
2a 191 252 96 125 127 115 897 521 235 278 no
3 100 157 100 50 105 139 137 178 109 95 no
4 96 145 97 105 113 136 467 216 159 137 no
5 121 205 101 191 126 105 114 112 107 111 no
6 116 124 123 108 119 97 154 136 151 112 no
7 113 123 179 111 111 71 316 259 120 122 no
8 174 234 127 146 121 161 167 140 108 105 no
9 97 98 72 144 123 111 65 84 114 101 no
10 99 142 116 129 124 194 271 122 132 889 no
  1. aPrednisolone, 2.5-10 mg/day.
  2. Controls, RA patients never treated with RTX; P23, pneumococcal polysaccharide vaccine 23; pre-RTX group, RA patients treated with RTX 6 days after vaccination; post-RTX group, RA patients treated with RTX 6 months before vaccination; RTX, rituximab.
  3. The levels of vaccine-specific antibodies at day 0 were taken as 100%. On day 21, the mean increase of antibody levels in the control group was 110%. This value indicated the cutoff for vaccination response in the RTX-treated patients.
  4. Bold numbers and gray boxes indicate levels equal to or greater than the cutoff level (110%).