Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatment

Rehnberg, Maria; Brisslert, Mikael; Amu, Sylvie; Zendjanchi, Kiandoht; Håwi, Gunilla; Bokarewa, Maria I

doi:10.1186/ar3047

Table 4 Individual responses of total IgG or IgG subclasses after influenza and pneumococcal polysaccharide immunization

From: Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatment

Patients	Total IgG	IgG₁	IgG₂	IgG₃	IgG₄	Total IgG	IgG₁	IgG₂	IgG₃	IgG₄	Previous RTX
Influenza						P23
Pre-RTX
1	176	289	99	125	117	152	95	105	110	115	1
2 ^a	94	86	98	89	74	102	454	534	203	117	no
3 ^a	163	128	110	112	111	204	262	107	95	115	no
4 ^a	154	292	198	178	108	335	77	167	129	148	no
5 ^a	132	368	99	121	123	217	246	458	128	113	no
Post-RTX
1^a	139	202	123	116	153	151	83	85	95	102	no
2	126	260	133	136	158	110	103	104	95	101	2
3	109	93	115	110	107	107	143	105	107	116	no
4	100	97	89	102	91	102	104	98	111	112	no
5^a	115	89	72	100	96	93	87	211	112	108	no
6^a	85	93	76	87	102	88	82	187	96	107	3
7	98	82	94	96	97	107	95	94	98	94	no
8	103	99	86	124	113	95	233	257	126	117	no
9^a	104	102	115	91	103	126	92	105	92	98	1
10	127	222	115	160	170	104	159	248	175	206	2
11^a	134	157	110	119	109	122	167	140	125	144	no
Controls
1	117	95	84	113	108	213	91	171	89	83	no
2^a	191	252	96	125	127	115	897	521	235	278	no
3	100	157	100	50	105	139	137	178	109	95	no
4	96	145	97	105	113	136	467	216	159	137	no
5	121	205	101	191	126	105	114	112	107	111	no
6	116	124	123	108	119	97	154	136	151	112	no
7	113	123	179	111	111	71	316	259	120	122	no
8	174	234	127	146	121	161	167	140	108	105	no
9	97	98	72	144	123	111	65	84	114	101	no
10	99	142	116	129	124	194	271	122	132	889	no

^aPrednisolone, 2.5-10 mg/day.
Controls, RA patients never treated with RTX; P23, pneumococcal polysaccharide vaccine 23; pre-RTX group, RA patients treated with RTX 6 days after vaccination; post-RTX group, RA patients treated with RTX 6 months before vaccination; RTX, rituximab.
The levels of vaccine-specific antibodies at day 0 were taken as 100%. On day 21, the mean increase of antibody levels in the control group was 110%. This value indicated the cutoff for vaccination response in the RTX-treated patients.
Bold numbers and gray boxes indicate levels equal to or greater than the cutoff level (110%).

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ISSN: 1478-6362

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