Mean C-reactive protein concentrations over time. Serum concentrations of C-reactive protein (CRP) were determined from baseline to week 24 for patients treated with placebo or adalimumab in ADEPT. Data are presented as mean values at each time point. Data are observed; n values at baseline/week 24 were 152/146 for placebo and 143/138 for adalimumab. P < 0.001 for the comparison of mean changes from baseline for adalimumab versus placebo at all time points after week 0.