| Controls, No | All RA cases | anti-CCP-positive RA | anti-CCP-negative RA |
---|
Subgroup | Â | No. | OR (95% CI) | No. | OR (95% CI) | No. | OR (95% CI) |
---|
GTG-negative†| 378 | 366 | 1 | 218 | 1 | 39 | 1 |
GTG-positive | 625 | 945 | 1.64 (1.31 to 2.05) | 602 | 1.73 (1.34 to 2.23) | 106 | 1.75 (1.15 to 2.68) |
SE-negative | 644 | 429 | 1 | 226 | 1 | 71 | 1 |
SE-positive | 359 | 882 | 4.31 (3.49 to 5.32) | 594 | 5.18 (4.54 to 7.45) | 74 | 2.31 (1.57 to 3.41) |
Non-smoking | 856 | 1,089 | 1 | 692 | 1 | 119 | 1 |
Smoking | 134 | 197 | 2.28 (1.47 to 3.52) | 119 | 2.17 (1.29 to 3.63) | 26 | 2.77 (1.30 to 5.90) |
- * Values are the number of subjects. OR and 95% CI for GTG carriage versus non-carriage were adjusted for age, sex, SE alleles and smoking. OR and 95% CI for SE carriage versus non-carriage were adjusted for age, sex, GTG carriage and smoking. OR and 95% CI for smoking versus non-smoking were adjusted for age, sex, GTG carriage and SE alleles. RA, rheumatoid arthritis; anti-CCP, anti-cyclic citrullinated peptide autoantibody; OR, odds ratios; CI, confidence intervals.
- †The letters in PADI4 haplotypes represent nucleotides in padi4_89, padi4_90, and padi4_92 SNPs, respectively. Extremely rare haplotypes ACG (n = 4), and GCC (n = 1) were excluded from analysis. Three subjects (two RA patients and one control) who carried ACC and a rare haplotype were excluded from the analysis and hence the GTG-negative subjects carried only ACC/ACC.