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Table 2 Association of PADI4 haplotypes, HLA-DRB1 SE alleles and smoking with susceptibility to anti-CCP-positive and -negative RA*

From: Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study

  Controls, No All RA cases anti-CCP-positive RA anti-CCP-negative RA
Subgroup   No. OR (95% CI) No. OR (95% CI) No. OR (95% CI)
GTG-negative† 378 366 1 218 1 39 1
GTG-positive 625 945 1.64 (1.31 to 2.05) 602 1.73 (1.34 to 2.23) 106 1.75 (1.15 to 2.68)
SE-negative 644 429 1 226 1 71 1
SE-positive 359 882 4.31 (3.49 to 5.32) 594 5.18 (4.54 to 7.45) 74 2.31 (1.57 to 3.41)
Non-smoking 856 1,089 1 692 1 119 1
Smoking 134 197 2.28 (1.47 to 3.52) 119 2.17 (1.29 to 3.63) 26 2.77 (1.30 to 5.90)
  1. * Values are the number of subjects. OR and 95% CI for GTG carriage versus non-carriage were adjusted for age, sex, SE alleles and smoking. OR and 95% CI for SE carriage versus non-carriage were adjusted for age, sex, GTG carriage and smoking. OR and 95% CI for smoking versus non-smoking were adjusted for age, sex, GTG carriage and SE alleles. RA, rheumatoid arthritis; anti-CCP, anti-cyclic citrullinated peptide autoantibody; OR, odds ratios; CI, confidence intervals.
  2. † The letters in PADI4 haplotypes represent nucleotides in padi4_89, padi4_90, and padi4_92 SNPs, respectively. Extremely rare haplotypes ACG (n = 4), and GCC (n = 1) were excluded from analysis. Three subjects (two RA patients and one control) who carried ACC and a rare haplotype were excluded from the analysis and hence the GTG-negative subjects carried only ACC/ACC.