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Table 3 Association of PADI4 haplotypes, HLA-DRB1 SE alleles and smoking with susceptibility to erosive and non-erosive RA*

From: Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study

  Controls, No All RA cases Erosive RA Non-erosive RA
Subgroup   No. OR (95% CI) No. OR (95% CI) No. OR (95% CI)
GTG-negative† 378 366 1 299 1 67 1
GTG-positive 625 945 1.64 (1.31 to 2.05) 771 1.62 (1.29 to 2.05) 174 1.62 (1.14 to 2.31)
SE-negative 644 429 1 346 1 83 1
SE-positive 359 882 4.31 (3.49 to 5.32) 724 4.45 (3.55 to 5.57) 158 4.16 (2.97 to 5.83)
Non-smoking 856 1,089 1 904 1 185 1
Smoking 134 197 2.28 (1.47 to 3.52) 146 2.01 (1.25 to 3.25) 51 3.83 (2.02 to 7.27)
  1. * Values are the number of subjects. OR and 95% CI for GTG carriage versus non-carriage were adjusted for age, sex, SE alleles and smoking. OR and 95% CI for SE carriage versus non-carriage were adjusted for age, sex, GTG carriage and smoking. OR and 95% CI for smoking versus non-smoking were adjusted for age, sex, GTG carriage and SE alleles. Erosive RA cases were classified as Steinbrocker scores II-IV. RA, rheumatoid arthritis; anti-CCP, anti-cyclic citrullinated peptide autoantibody; OR, odds ratios; CI, confidence intervals.
  2. † Three subjects (two RA patients and one control) who carried ACC and a rare haplotype were excluded from the analysis and hence the GTG-negative subjects carried only ACC/ACC.