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Table 4 Interaction between PADI4 haplotypes and SE alleles in susceptibility to anti-CCP-positive and -negative RA*

From: Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study

  Controls, No All RA cases anti-CCP-positive RA anti-CCP-negative RA
Subgroup   No. OR (95% CI) No. OR (95% CI) No. OR (95% CI)
GTG and SE carriage 1,003 1,311   820   145  
   GTG-negative/SE-negative 245 109 1 50 1 18 1
   GTG-negative/SE-positive 133 257 5.17 (3.57 to 7.48) 168 8.20 (5.23 to 12.85) 21 2.40 (1.18 to 4.89)
   GTG-positive/SE-negative 399 320 1.89 (1.37 to 2.61) 176 2.32 (1.54 to 3.49) 53 1.80 (0.99 to 3.25)¶
   GTG-positive/SE-positive† 226 625 7.46 (5.38 to 10.36) 426 11.63 (7.73 to 17.51) 53 4.10 (2.23 to 7.53)
Diplotype and SE carriage 1,003 1,311   820   145  
   ACC/ACC/SE-negative 245 109 1 50 1 18 1
   ACC/GTG/SE-negative 290 217 1.72 (1.22 to 2.42) 122 2.14 (1.39 to 3.30) 33 1.52 (0.81 to 2.88)¶
   GTG/GTG/SE-negative 109 103 2.39 (1.56 to 3.66) 54 2.85 (1.68 to 4.85) 20 2.58 (1.24 to 5.37)
   ACC/ACC/SE-positive 133 257 5.19 (3.58 to 7.51) 168 8.24 (5.25 to 12.92) 21 2.41 (1.18 to 4.92)
   ACC/GTG/SE-positive 179 428 6.23 (4.42 to 8.77) 298 9.87 (6.47 to 15.06) 31 2.90 (1.50 to 5.60)
   GTG/GTG/SE-positive‡ 47 197 12.74 (8.03 to 20.23) 128 19.45 (11.32 to 33.42) 22 9.59 (4.39 to 20.98)
  1. * OR and 95% CI were adjusted for age, sex, and smoking. RA, rheumatoid arthritis; anti-CCP, anti-cyclic citrullinated peptide autoantibody; OR, odds ratios; CI, confidence intervals.
  2. † The attributable proportion (95% CI) due to interaction was 0.16 (-0.10 to 0.42) in anti-CCP-positive RA and 0.19 (-0.26 to 0.63) in anti-CCP-negative RA.
  3. ‡ The attributable proportion (95% CI) due to interaction was 0.45 (0.20 to 0.71) in anti-CCP-positive RA and 0.61 (0.29 to 0.92) in anti-CCP-negative RA.
  4. ¶Association was not significant (P = 0.05 and P = 0.20, respectively).