Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 5 Interaction between PADI4 haplotypes and SE alleles in susceptibility to erosive and non-erosive RA *

From: Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study

  Controls, No All RA cases Erosive RA Non-erosive RA
Subgroup   No. OR (95% CI) No. OR (95% CI) No. OR (95% CI)
GTG and SE carriage 1,003 1,311   1,070   241  
   GTG-negative/SE-negative 245 109 1 89 1 20 1
   GTG-negative/SE-positive 133 257 5.17 (3.57 to 7.48) 210 5.05 (3.41 to 7.47) 47 5.70 (3.04 to 10.67)
   GTG-positive/SE-negative 399 320 1.89 (1.37 to 2.61) 257 1.80 (1.27 to 2.54) 63 2.11 (1.19 to 3.75)
   GTG-positive/SE-positive† 226 625 7.46 (5.38 to 10.36) 514 7.52 (5.31 to 10.65) 111 7.73 (4.39 to 13.61)
Diplotype and SE carriage 1,003 1,311   1,070   241  
   ACC/ACC/SE-negative 245 109 1 89 1 20 1
   ACC/GTG/SE-negative 290 217 1.72 (1.22 to 2.42) 177 1.65 (1.14 to 2.38) 40 1.85 (1.01 to 3.41)
   GTG/GTG/SE-negative 109 103 2.39 (1.56 to 3.66) 80 2.22 (1.41 to 3.50) 23 2.87 (1.40 to 5.86)
   ACC/ACC/SE-positive 133 257 5.19 (3.58 to 7.51) 210 5.07 (3.42 to 7.51) 47 5.71 (3.05 to 10.70)
   ACC/GTG/SE-positive 179 428 6.23 (4.42 to 8.77) 357 6.29 (4.37 to 9.03) 71 6.16 (3.41 to 11.11
   GTG/GTG/SE-positive‡ 47 197 12.74 (8.03 to 20.23) 157 12.98 (7.97 to 21.14) 40 14.47 (7.11 to 29.45)
  1. * OR and 95% CI were adjusted for age, sex, and smoking. Erosive RA cases were classified as Steinbrocker scores II-IV. RA, rheumatoid arthritis; OR, odds ratios; CI, confidence intervals.
  2. † The attributable proportion (95% CI) due to interaction was 0.19 (-0.06 to 0.43) in erosive RA and 0.11 (-0.27 to 0.48) in non-erosive RA.
  3. ‡ The attributable proportion (95% CI) due to interaction was 0.48 (0.25 to 0.72) in erosive RA and 0.46 (0.14 to 0.78) in non-erosive RA.