Table 5 Interaction between PADI4 haplotypes and SE alleles in susceptibility to erosive and non-erosive RA *
| Â | Controls, No | All RA cases | Erosive RA | Non-erosive RA | |||
|---|---|---|---|---|---|---|---|
Subgroup | Â | No. | OR (95% CI) | No. | OR (95% CI) | No. | OR (95% CI) |
GTG and SE carriage | 1,003 | 1,311 | Â | 1,070 | Â | 241 | Â |
   GTG-negative/SE-negative | 245 | 109 | 1 | 89 | 1 | 20 | 1 |
   GTG-negative/SE-positive | 133 | 257 | 5.17 (3.57 to 7.48) | 210 | 5.05 (3.41 to 7.47) | 47 | 5.70 (3.04 to 10.67) |
   GTG-positive/SE-negative | 399 | 320 | 1.89 (1.37 to 2.61) | 257 | 1.80 (1.27 to 2.54) | 63 | 2.11 (1.19 to 3.75) |
   GTG-positive/SE-positive†| 226 | 625 | 7.46 (5.38 to 10.36) | 514 | 7.52 (5.31 to 10.65) | 111 | 7.73 (4.39 to 13.61) |
Diplotype and SE carriage | 1,003 | 1,311 | Â | 1,070 | Â | 241 | Â |
   ACC/ACC/SE-negative | 245 | 109 | 1 | 89 | 1 | 20 | 1 |
   ACC/GTG/SE-negative | 290 | 217 | 1.72 (1.22 to 2.42) | 177 | 1.65 (1.14 to 2.38) | 40 | 1.85 (1.01 to 3.41) |
   GTG/GTG/SE-negative | 109 | 103 | 2.39 (1.56 to 3.66) | 80 | 2.22 (1.41 to 3.50) | 23 | 2.87 (1.40 to 5.86) |
   ACC/ACC/SE-positive | 133 | 257 | 5.19 (3.58 to 7.51) | 210 | 5.07 (3.42 to 7.51) | 47 | 5.71 (3.05 to 10.70) |
   ACC/GTG/SE-positive | 179 | 428 | 6.23 (4.42 to 8.77) | 357 | 6.29 (4.37 to 9.03) | 71 | 6.16 (3.41 to 11.11 |
   GTG/GTG/SE-positive‡ | 47 | 197 | 12.74 (8.03 to 20.23) | 157 | 12.98 (7.97 to 21.14) | 40 | 14.47 (7.11 to 29.45) |