Skip to main content

Advertisement

Table 1 Summary table of SNPs described in the literature and linkage disequilibrium relationship with rs6822844 and rs17388568

From: Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844with rheumatoid arthritis at a genome-wide level of significance

  Location (dbSNP130) r2 in relation to SNP Gene Disease
SNP   rs6822844 rs17388568   T1D CeD GD UC CD JIA PSA PS RA SLE
rs6822844 123728871 1 0.07 - [13, 21]
- -
[16, 40, 41]
- -
  [14, 15, 38]
- -
[14, 15]
- -
[19]
- -
[18]
- -
[18]
=
[6, 12, 21]
-
 
rs13151961 123334952 0.89 0.10 KIAA1109 (intron)   [16, 20, 40, 41]
- -
  [14]
- -
[14]
-
  [18]
- -
[18]
=
  
rs6840978 123774157 0.73 0.13 -   [16, 40, 42]
- -
  [14, 38]
- -
[14]
-
     
rs13119723 123437763 0.65 0.07 KIAA1109 (intron)   [16, 40, 42]
- -
  [14, 38]
- -
[14]
-
     
rs11938795 123292459 0.53 0.16 -   [16, 42]
- -
  [15]
-
[15]
- -
     
rs11734090 123447563 0.53 0.16 KIAA1109 (intron)   [16, 42]
-
        
rs12642902 123727951 0.45 0.22 -   [16, 42]
-
        
rs7684187 123560609 0.44 0.19 TENR (intron)   [16, 42]
-
     [18]
- -
[18]
-
  
rs907715 123754503 0.41 0.22 IL21 (intron)           [17]
- -
rs17388568 123548812 0.07 1 TENR (intron) [13]
+
  [13]
+
      [12]
=
 
rs2221903 123758362 0.08 0.88 IL21 (intron)           [17]
+
rs3136534 123589223 0.10 0.82 - [13]
+
         
rs4505848 123351942 0.10 0.82 KIAA1109 (intron) [43]
+
        [20]
=
 
rs6836189 123760791 - - IL21 (intron) [13]
+
         
  1. CD: Crohn's disease; CeD: Celiac's disease; GD: Grave's disease; JIA: juvenile idiopathic arthritis; RA: rheumatoid arthritis; T1D: type 1 diabetes; PS: psoriasis; PSA: psoriatic arthritis; SLE: systemic lupus erythematosus; UC: ulcerative colitis. The SNPs are arranged into separate LD blocks in relation to rs6822844 and rs17388568. Key to symbols: OR < 0.8, - -; OR 0.8 to < 1.0, -; no effect, =; OR > 1.0 to 1.2, +; OR > 1.2, +