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Table 1 Summary table of SNPs described in the literature and linkage disequilibrium relationship with rs6822844 and rs17388568

From: Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844with rheumatoid arthritis at a genome-wide level of significance

 

Location (dbSNP130)

r2 in relation to SNP

Gene

Disease

SNP

 

rs6822844

rs17388568

 

T1D

CeD

GD

UC

CD

JIA

PSA

PS

RA

SLE

rs6822844

123728871

1

0.07

-

[13, 21]

- -

[16, 40, 41]

- -

 

[14, 15, 38]

- -

[14, 15]

- -

[19]

- -

[18]

- -

[18]

=

[6, 12, 21]

-

 

rs13151961

123334952

0.89

0.10

KIAA1109 (intron)

 

[16, 20, 40, 41]

- -

 

[14]

- -

[14]

-

 

[18]

- -

[18]

=

  

rs6840978

123774157

0.73

0.13

-

 

[16, 40, 42]

- -

 

[14, 38]

- -

[14]

-

     

rs13119723

123437763

0.65

0.07

KIAA1109 (intron)

 

[16, 40, 42]

- -

 

[14, 38]

- -

[14]

-

     

rs11938795

123292459

0.53

0.16

-

 

[16, 42]

- -

 

[15]

-

[15]

- -

     

rs11734090

123447563

0.53

0.16

KIAA1109 (intron)

 

[16, 42]

-

        

rs12642902

123727951

0.45

0.22

-

 

[16, 42]

-

        

rs7684187

123560609

0.44

0.19

TENR (intron)

 

[16, 42]

-

    

[18]

- -

[18]

-

  

rs907715

123754503

0.41

0.22

IL21 (intron)

         

[17]

- -

rs17388568

123548812

0.07

1

TENR (intron)

[13]

+

 

[13]

+

     

[12]

=

 

rs2221903

123758362

0.08

0.88

IL21 (intron)

         

[17]

+

rs3136534

123589223

0.10

0.82

-

[13]

+

         

rs4505848

123351942

0.10

0.82

KIAA1109 (intron)

[43]

+

       

[20]

=

 

rs6836189

123760791

-

-

IL21 (intron)

[13]

+

         
  1. CD: Crohn's disease; CeD: Celiac's disease; GD: Grave's disease; JIA: juvenile idiopathic arthritis; RA: rheumatoid arthritis; T1D: type 1 diabetes; PS: psoriasis; PSA: psoriatic arthritis; SLE: systemic lupus erythematosus; UC: ulcerative colitis. The SNPs are arranged into separate LD blocks in relation to rs6822844 and rs17388568. Key to symbols: OR < 0.8, - -; OR 0.8 to < 1.0, -; no effect, =; OR > 1.0 to 1.2, +; OR > 1.2, +