Table 2 Association analysis of the KIAA1109-TENR-IL2-IL21 SNP rs6822844 with RA in seven European case control sample sets
| Â | Genotype, no. (frequency)1,2 | Minor allele, no. (frequency) | OR [95% CI] | P | ||
|---|---|---|---|---|---|---|
Sample Set | 1/1 | 1/2 | 2/2 | Â | Â | Â |
WTCCC [22] | Â | Â | Â | Â | Â | Â |
Case | 1,242 (0.669) | 553 (0.298) | 61 (0.033) | 675 (0.181) | 0.91 (0.82 to 1.02) | 0.10 |
Control | 1,881 (0.642) | 958 (0.326) | 94 (0.032) | 1,146 (0.195) | Â | Â |
Zhernakova [21] | Â | Â | Â | Â | Â | Â |
Case | 748 (0.739) | 243 (0.240) | 21 (0.021) | 285 (0.141) | 0.72 (0.61 to 0.86) | 2.0 × 10-4 |
Control | 613 (0.663) | 280 (0.303) | 31 (0.034) | 342 (0.185) | Â | Â |
NARAC [3] | Â | Â | Â | Â | Â | Â |
Case | NA | NA | NA | NA | 0.84 (0.74 to 0.96) | 0.011 |
Control | NA | NA | NA | NA | Â | Â |
Teixeira [20] | Â | Â | Â | Â | Â | Â |
Case | 327 (0.753) | 99 (0.228) | 8 (0.018) | 115 (0.132) | 0.85 (0.65 to 1.12) | 0.24 |
Control | 313 (0.721) | 110 (0.253) | 11 (0.025) | 132 (0.152) | Â | Â |
Barton [12] | Â | Â | Â | Â | Â | Â |
Case | 2,739 (0.705) | 1,052 (0.271) | 95 (0.024) | 1,242 (0.160) | 0.86 (0.79 to 0.94) | 5.4 × 10-4 |
Control | 2,326 (0.674) | 1,003 (0.290) | 125 (0.036) | 1,253 (0.181) | Â | Â |
Daha [6] | Â | Â | Â | Â | Â | Â |
Case | NA | NA | NA | 285 (0.162) | 0.84 (0.70 to 1.00) | 0.051 |
Control | NA | NA | NA | 325 (0.188) | Â | Â |
Australasian | Â | Â | Â | Â | Â | Â |
Case | 583 (0.699) | 221 (0.265) | 30 (0.036) | 281 (0.168) | 0.95 (0.80 to 1.12) | 0.54 |
Control | 743 (0.674) | 330 (0.299) | 29 (0.026) | 388 (0.176) | Â | Â |