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Table 2 Association analysis of the KIAA1109-TENR-IL2-IL21 SNP rs6822844 with RA in seven European case control sample sets

From: Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844with rheumatoid arthritis at a genome-wide level of significance

  Genotype, no. (frequency)1,2 Minor allele, no. (frequency) OR [95% CI] P
Sample Set 1/1 1/2 2/2    
WTCCC [22]       
Case 1,242 (0.669) 553 (0.298) 61 (0.033) 675 (0.181) 0.91 (0.82 to 1.02) 0.10
Control 1,881 (0.642) 958 (0.326) 94 (0.032) 1,146 (0.195)   
Zhernakova [21]       
Case 748 (0.739) 243 (0.240) 21 (0.021) 285 (0.141) 0.72 (0.61 to 0.86) 2.0 × 10-4
Control 613 (0.663) 280 (0.303) 31 (0.034) 342 (0.185)   
NARAC [3]       
Case NA NA NA NA 0.84 (0.74 to 0.96) 0.011
Control NA NA NA NA   
Teixeira [20]       
Case 327 (0.753) 99 (0.228) 8 (0.018) 115 (0.132) 0.85 (0.65 to 1.12) 0.24
Control 313 (0.721) 110 (0.253) 11 (0.025) 132 (0.152)   
Barton [12]       
Case 2,739 (0.705) 1,052 (0.271) 95 (0.024) 1,242 (0.160) 0.86 (0.79 to 0.94) 5.4 × 10-4
Control 2,326 (0.674) 1,003 (0.290) 125 (0.036) 1,253 (0.181)   
Daha [6]       
Case NA NA NA 285 (0.162) 0.84 (0.70 to 1.00) 0.051
Control NA NA NA 325 (0.188)   
Australasian       
Case 583 (0.699) 221 (0.265) 30 (0.036) 281 (0.168) 0.95 (0.80 to 1.12) 0.54
Control 743 (0.674) 330 (0.299) 29 (0.026) 388 (0.176)   
  1. (1) There were no significant departures from Hardy-Weinberg equilibrium, all P > 0.06
  2. (2) Genotype data were imputed in the WTCCC sample set, and directly genotyped in all others