Figure 1

Monocytes were isolated from the peripheral blood (PB) of normal (NL) volunteers and placed in a modified Boyden chemotaxis system opposite graded increases in concentration of rhuIL-18. As shown, IL-18 stimulates chemotaxis for human monocytes in a dose-dependent manner, and is maximal between 0.25 nM and 25 nM (figure representative of three separate experiments).