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Table 1 Laboratory tests for citrullinated antigens

From: 21st European Workshop for Rheumatology Research, Vienna, Austria, 1–4 March 2001

Author Substrate Method Sensitivity Specificity Comments
Bozic (P4) Cyclic citrullinated peptide (CCP) ELISA 58% ND Tested 97 RA patients who were RF-positive or RF-negative.
      Small study, lower sensitivity than previously reported.
Union (P6) In vitro citrullinated filaggrin; 2 citrullinated peptides Line immunoassay 65% (using 3 markers); 61.8% (using 2 peptides) 97.6% (using 3 markers); 98.4% (using 2 peptides) Tested 335 RA patients and 254 patients with non-RA rheumatologic conditions retrospectively. Results similar to those reported previously for CCP.
Vincent (P7) Deiminated recombinant rat filaggrin (ArFA); antikeratin antibodies ELISA+ indirect immuno-fluorescence of rat esophagus 67% <99% Tested 714 patients with rheumatic disease, of whom 241 had RA. Requires sequential testing to maintain utility at 99%. The sensitivity for arFA ELISA alone (at 95% specificity) was 75%.
  1. ELISA = enzyme-linked immunosorbent assay; ND = no data; RF = rheumatoid factor.